Table 5.

Multivariable Analysis: Predictors of 21-day mortality in 295 patients with non-acetaminophen-induced Acute Liver Failure.

	Univariate (N=308)			Multivariate (N=295)
Measures	Odds Ratio	95% CI	p-value	Odds Ratio	95% CI	p-value
Age	1.017	1.002 – 1.032	0.027	1.022	1.002 – 1.043	0.029
Male	1.303	0.824 – 2.060	0.258	0.770	0.410 – 1.446	0.417
White	0.952	0.593 – 1.527	0.837	0.783	0.412 – 1.489	0.455
Transplant**	0.060	0.029 – 0.127	<0.001
Lactate	1.017	0.994 – 1.040	0.145
MELD**	1.050	1.022 – 1.079	<0.001
Mechanical ventilation	1.098	0.624 – 1.934	0.745
Vasopressors	2.635	1.656 – 4.194	<0.001	2.133	1.160 – 3.923	0.015
Hemodialysis	1.417	0.896 – 2.240	0.136
Enrolment Year	0.957	0.860 – 1.066	0.428
High Enrolling site*	0.976	0.602 – 1.580	0.920	1.316	0.673 – 2.571	0.423
MELD*Transplant**						0.004
ICP Monitor	0.708	0.412 – 1.219	0.213	3.040	1.258 – 7.344	0.014

• 13 patients excluded for missing data
• *High enrolling site defined as a site that enrolled more than 6 subjects per year on average while open from 1998 – 2012 (median for all sites).
• Final model was adjusted for site, age, gender, race, transplant status, high vs. low enrolling site and presence of ICP monitor
• Other variables were included in final model if significant on univariable logistic regression (MELD on admission and vasopressors during 7 days in study)
• **There was a significant interaction MELD and transplant status; an interaction term was included in the final model which was statistically significant (p=0.003)
  • In non-transplanted patients, increasing meld was significantly associated with worse outcomes when accounting for the interaction with LT
• The multivariable model had a c-statistic of 0.86, Hosmer-Lemeshow p=0.68