Table 1.
Proposed interaction partners of RECQL5 till date.
| Protein | Location | Methods | Region | Function | References |
|---|---|---|---|---|---|
| FEN1 | Nuc | CBD-PD | ND | RECQL5 stimulates flap endonuclease activity |
Speina et al. (2010) |
| TOPO IIa | Nuc | CoIP | ND | RECQL5 stimulates DNA decatenation activity |
Ramamoorthy et al. (2012) |
| TOPO IIIa/b | Nuc | CoIP | ND | ND | Shimamoto et al. (2000) |
| PCNA | Nuc | GST-PD | 542–991 | ND | Kanagaraj et al. (2006) |
| WRN | Nuc | CoIP | ND | RECQL5 stimulates WRN helicase activity |
Popuri et al. (2012) |
| Rad51 | Nuc | CoIP, CBD-PD | 515–653 | RECQL5 disrupts Rad51 filament formation |
Schwendener et al. (2010) |
| Mrell | Nuc | MS, CoIP | ND | RECQL5 inhibits Mrell exonuclease activity |
Zheng et al. (2009) |
| NBS1 | Nuc | MS, CoIP | ND | ND | Zheng et al. (2009) |
| RAD50 | Nuc | MS, CoIP | ND | ND | Zheng et al. (2009) |
| RNAP II | Nuc | MS, CoIP | KIX, SRI | RECQL5 inhibits RNA Pol II transcription |
Aygun et al. (2008), Islam et al. (2010) |
| SWI/SNF comp | Nuc | MS, CoIP | ND | ND | Zhou et al. (2010) |
| PARP-1 | Nuc | CoIP | ND | PARP-1 regulates | Tadokoro et al. (2012) |
| RECQL5 helicase activity |
The interaction partners of RECQL5 in various DNA metabolic processes such as DNA replication, transcription and HR. The modes of functional interaction and the interacting domains involved, with the appropriate references are also listed.