Fig. 2.

TROX-1 significantly reduced the dynamic brush, mechanical punctate and thermal-evoked neuronal responses in the MIA group. Following stable baseline recordings, OA or sham rats were dosed spinally with 0.1 μg, and 1 μg TROX-1 in a volume of 50 μl. The evoked neuronal response to electrical (a, b), dynamic brush (c, d), mechanical punctate (e, f) and thermal stimulation (g, h) of the peripheral receptive field in sham (n = 6, left panel) and MIA (n = 6, right panel) rats were recorded. Asterisks and bars denote statistically significant main effect (one-way RM ANOVA). (+) denotes significant difference between baseline and 0.1 μg:⁺P < 0.05, ⁺⁺P < 0.01. (^∗) denotes significant difference between baseline and 1 μg TROX-1: ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 (two-way RM ANOVA with Bonferroni post-hoc test). All data are presented as mean ± SEM. PD = post-discharge, I = Input and W = wind up.