Table S3.
Chi-square test “Is there evidence that acceptance rates above the accepted thresholds are higher for some therapeutic areas than for others?”
| Number accepted | Number rejected | Total | Expected accepted | Expected rejected | Chi squared accepted | Chi squared rejected | |
|---|---|---|---|---|---|---|---|
| Malignant disease and immunosuppression | 37 | 94 | 131 | 37.00896861 | 93.99103139 | 2.17×10–6 | 8.56×10–7 |
| Musculoskeletal and joint diseases | 6 | 10 | 16 | 4.520179372 | 11.47982063 | 0.484465 | 0.020055 |
| Infections | 3 | 11 | 14 | 3.955156951 | 10.04484305 | 0.230667 | 0.090825 |
| Nutrition and blood | 3 | 11 | 14 | 3.955156951 | 10.04484305 | 0.230667 | 0.090825 |
| Endocrine system | 3 | 8 | 11 | 3.107623318 | 7.892376682 | 0.003727 | 0.001468 |
| Skin | 4 | 4 | 8 | 2.260089686 | 5.739910314 | 1.339455 | 0.52741 |
| Central nervous system | 2 | 5 | 7 | 1.977578475 | 5.022421525 | 0.000254 | 0.0001 |
| Gastrointestinal system | 1 | 5 | 6 | 1.695067265 | 4.304932735 | 0.285014 | 0.112224 |
| Eye | 2 | 4 | 6 | 1.695067265 | 4.304932735 | 0.054856 | 0.021599 |
| Respiratory system | 1 | 4 | 5 | 1.412556054 | 3.587443946 | 0.120493 | 0.047444 |
| Obstetrics, gynecology, and urinary tract disorders | 1 | 2 | 3 | 0.847533632 | 2.152466368 | 0.027428 | 0.0108 |
| Cardiovascular system | 0 | 1 | 1 | 0.282511211 | 0.717488789 | 0.282511 | 0.111239 |
| Chi-square total | 4.09353 | ||||||
| P-value (χ2 test) | 0.967101 | ||||||
| P-value (df =11) | 0.967101 |