Figure 1.

Global view of DNA copy number variation patterns in primary and secondary tumors. (A) Genomic visualization of CNV patterns in the two tumor lesions. The outer circle indicates chromosome 1 to chromosome X, the middle circle represents the DNA copy number alteration of the primary tumor, and the inner circle represents the DNA copy number alteration of the secondary tumor. The colored blocks (red for gain, blue for loss) indicate the average log₁₀ ratio value (only showing those reaching the cut-off 0.2) after segmentation by the circular binary segmentation algorithm. (B) Statistics of altered DNA regions (segments) between the primary and secondary tumors. The x-axis presents the CNV type, and the y-axis indicates the altered DNA region numbers. CNV, copy number variations.