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Fluorescence recovery after photobleaching (FRAP) measurements of sarcomeric actin in normal and DMD hiPSC-CMs demonstrate that DMD hiPSC-CMs have significantly slower actin turnover than normal control. Slower actin turnover may explain why DMD hiPSC-CMs are less responsive to extracellular matrix cues such as nanotopography, as the cells are less able to adapt to changes in their environment.
