Table 2. PK parameters following dosing with DMS5540 as determined by WinNonLin analysis.
| DMS5540 Dose (mg/kg) | T ½ (hr) | Tmax (hr) | Mean Cmax (μg/mL) | SE of Cmax | AUC(0-∞) (hr*μg/mL) | Vz (mL/kg) | Cl (mL/kg/hr) | MRT (hr) |
|---|---|---|---|---|---|---|---|---|
| 0.1 | 3.3 | 0.17 | 0.9 | 0.06 | 4.1 | 117.9 | 24.5 | 3.9 |
| 1 | 8.6 | 0.17 | 18.0 | 0.91 | 169.8 | 73.0 | 5.9 | 11.5 |
| 10 | 23.2 | 0.17 | 178.5 | 3.35 | 3028.6 | 110.6 | 3.3 | 27.2 |
Abbreviations: T1/2: terminal half-life of DMS5540; Tmax: Time at which maximum concentration is reached; Mean Cmax: mean maximum concentration across 3 mice; SE of Cmax: Standard Error of Cmax; AUC: Area Under the concentration/time Curve extrapolated to infinity; Vz: volume of distribution over terminal phase; Cl: Clearance; MRT: Mean Residence Time.