Table 3. Statistical analysis comparing effects of dAb dosing on IL-6 serum levels after a TNF-α challenge.
| Comparison (mg/kg) | Adjusted Geometric Means (IL-6/pg/ml) | Ratio (Test/Ref) | 95% CI # | P-Value | |
|---|---|---|---|---|---|
| Test | Reference TNF or 5538 | ||||
| 5540 (0.1) vs TNF Only | 31.07 | 95.16 | 0.33 | (0.07, 1.47) | 0.1419 |
| 5540 (0.3) vs TNF Only | 16.46 | 95.16 | 0.17 | (0.04, 0.78) | 0.0231* |
| 5540 (1.0) vs TNF Only | 4.1 | 95.16 | 0.04 | (0.01, 0.19) | 0.0001* |
| 5540 (3.0) vs TNF Only | 13.38 | 95.16 | 0.14 | (0.03, 0.63) | 0.0116* |
| 5538 (3.0) vs TNF Only | 64.17 | 95.16 | 0.67 | (0.14, 3.20) | 0.6143 |
| 5540 (0.1) vs 5538 (3.0) | 31.07 | 64.17 | 0.48 | (0.10, 2.30) | 0.355 |
| 5540 (0.3) vs 5538 (3.0) | 16.46 | 64.17 | 0.26 | (0.05, 1.22) | 0.086 |
| 5540 (1.0) vs 5538 (3.0) | 4.1 | 64.17 | 0.06 | (0.01, 0.30) | 0.001* |
| 5540 (3.0) vs 5538 (3.0) | 13.38 | 64.17 | 0.21 | (0.04, 0.99) | 0.049* |
* Statistically Significant
# The point estimate provides the best estimate of the true ratio. The 95% confidence interval provides a range of plausible values for the ratio or difference.