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. 2015 Sep 9;11(9):e1005507. doi: 10.1371/journal.pgen.1005507

Fig 4. Ability of Pol IV mutants to tolerate MMS-induced DNA damage in vivo.

Fig 4

(A) The dependence of MMS-induced mutagenesis on Pol IV (dinB) and Pol V (umuDC) function using strains RW118, RW120 (ΔumuDC), VB102 (ΔdinB), and VB103 (ΔdinB ΔumuDC), and (B) the ability of ~4-fold higher than SOS-induced levels of wild type or mutant Pol IV proteins (expressed from a plasmid) to suppress the frequency of Pol V-dependent MMS-induced mutagenesis of strain RW118 by competing with Pol V was measured as described in Materials and Methods and [33]. Results represent the average of at least 4 independent experiments ± one standard deviation. Symbols are as follows: **, p<0.0001; *, p<0.05.