Fig. 4. Log–log plots for Scenario 1 (Sec63 is tethered to the membrane) detailing the BiP ratio (total BiP concentration on the membrane divided by the total BiP concentration in the lumen) for total BiP varying from 0.55 to 55 mM (104 to 106 molecules) for the modified ODE (left) and PDE (right) models.
Graphs show three sets of different total Sec63 concentrations (corresponding to 10 000, 17 700 and 25 000 molecules). When Sec63 is allowed to diffuse (Scenario 2) or is removed from the system (Scenario 3), the BiP ratio is uniformly one