Table 2. Differentially Expressed Genes Identified in Three Types of Studied Rheumatic Diseases.
| Gene Symbol | P-value | Meta P-value | ||||||
|---|---|---|---|---|---|---|---|---|
| RA1 | RA2 | SLE1 | SLE2 | OA | AS | Fisher | Max-P | |
| TNFSF10 a | 1.80E-04 | 6.00E-04 | 9.00E-04 | 1.00E-20 | 5.66E-01 | 1.50E-03 | 1.07E-19 | 1.65E-01 |
| LY96 a | 1.20E-04 | 2.44E-02 | 4.49E-02 | 1.00E-20 | 1.90E-02 | 7.95E-05 | 1.07E-19 | 2.74E-18 |
| PRKCH a | 5.13E-06 | 7.25E-02 | 2.52E-01 | 5.86E-02 | 3.21E-05 | 5.10E-04 | 1.07E-19 | 1.01E-02 |
| TXN a | 1.00E-20 | 1.80E-02 | 1.79E-01 | 1.00E-20 | 6.51E-01 | 1.28E-05 | 1.07E-19 | 2.71E-01 |
| CX3CR1 a | 7.07E-02 | 2.00E-04 | 3.90E-02 | 1.52E-02 | 1.00E-20 | 3.46E-05 | 1.07E-19 | 2.74E-18 |
| TXN b | 1.63E-18 | 5.83E-02 | 7.20E-01 | 1.61E-19 | 7.79E-01 | 7.33E-03 | 1.07E-19 | 2.71E-01 |
| CX3CR1 b | 2.58E-01 | 6.76E-03 | 5.83E-01 | 4.68E-02 | 2.00E-18 | 8.18E-03 | 1.07E-19 | 2.74E-18 |
| TLR5 b | 4.34E-02 | 6.76E-03 | 3.77E-01 | 6.94E-05 | 5.49E-03 | 4.05E-01 | 1.07E-19 | 2.28E-03 |
| TIA1 b | 3.49E-01 | 6.76E-03 | 7.36E-01 | 1.09E-03 | 6.66E-03 | 5.33E-01 | 1.07E-19 | 1.58E-02 |
| PRF1 b | 6.26E-02 | 8.82E-03 | 7.08E-01 | 6.60E-04 | 1.88E-03 | 6.43E-02 | 1.07E-19 | 4.76E-04 |
Presented are p values from tests of differential expression between rheumatic patients and normal controls.
a Genes identified from the top 100 ranked genes across the six datasets. The corresponding p-values are moderate p-values from the moderated-t statistic.
b Genes identified based on p-values adjusted by the Benjamini-Hochberg method. The corresponding p-values are adjusted p-values.
Each of the genes was identified from three of the four diseases, and the p values of the corresponding datasets are in bold.
Significant p values in the meta-analysis are in bold.