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. 2015 Sep 9;10(9):e0136893. doi: 10.1371/journal.pone.0136893

Fig 6. DNMT activity and global DNA methylation increased in CPR cells, but not in CPR cells under EGFR inhibition.

Fig 6

A) Normalized DNMT activity in control, CPR cells as well as cells that received the EGFR inhibitor Erlotinib only or Erlotinib + cisplatin during the cisplatin resistance paradigm, n = 4. One-way ANOVA followed by Dunnet’s post hoc showed that Erlotinib co-treatment with cisplatin in the cisplatin resistance paradigm attenuated the increase in DNMT activity observed in CPR cells. B) Normalized percent 5-methylcytosine (5mC) or DNA global methylation for control, CPR cells as well as cells that received the EGFR inhibitor Erlotinib only or Erlotinib + cisplatin during the cisplatin resistance paradigm, n = 4–6. One way ANOVA followed by Tukey’s post hoc revealed a significant increase in global DNA methylation in CPR cells, but not in cells that received Erlotinib *p<0.05.