Table 1.
Membrane capacitance and characteristics of ICa measured at 0 mV in intact (A) and detubulated (B) Sham and CAL myocytes (before correction for incomplete detubulation).
| Sham | CAL | |
|---|---|---|
| A: ICa properties recorded in intact myocytes | ||
| n (cells) | 37 | 33 |
| Capacity (pF) | 260 ± 9 | 365 ± 13⁎⁎⁎ |
| Peak ICa (pA) | − 1561 ± 81 | − 2056 ± 74⁎⁎⁎ |
| Peak ICa (pA/pF) | − 6.0 ± 0.2 | − 5.8 ± 0.3 |
| ICa inactivation | ||
| Taufast | 23.9 ± 1.0 | 23.0 ± 1.1 |
| Tauslow | 97.2 ± 1.9 | 93.9 ± 2.4 |
| B: ICa properties recorded in detubulated myocytes | ||
| n (cells) | 28 | 31 |
| Capacity (pF) | 178 ± 9 ††† | 271 ± 10 ⁎⁎⁎,††† |
| Peak ICa (pA) | − 699 ± 31 ††† | − 1465 ± 98 ⁎⁎⁎,††† |
| Peak ICa (pA/pF) | − 4.0 ± 0.2 ††† | − 5.4 ± 0.3⁎⁎⁎ |
| ICa inactivation | ||
| Taufast | 26.3 ± 1.1 | 23.2 ± 1.0⁎ |
| Tauslow | 110.0 ± 3.4 ††† | 103.6 ± 4.0 † |
⁎⁎p < 0.01. vs Sham.
†† p < 0.01 vs control (intact) myocytes.
⁎
p < 0.05 vs Sham.
⁎⁎⁎
p < 0.001 vs Sham.
†
p < 0.05 vs control (intact) myocytes.
†††
p < 0.001 vs control (intact) myocytes.