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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Int J Biochem Cell Biol. 2015 Jul 17;67:148–157. doi: 10.1016/j.biocel.2015.07.006

Fig. 1.

Fig. 1

Role of Jmjd3 in development. (A) Negative feedback of Noggin to regulate Jmjd3-mediated activation of Noggin via inhibition of BMP activity. Upon treatment with Nodal, JMJD3 recruitment to SMAD2/3 genes is associated with decreased enrichment of H3K27me3 marks at SMAD2/3 genes (Kim et al., 2011), leading to the expression of the homeobox protein goosecoid (GSC) initiation of endoderm development. (B) During early endoderm differentiation, TBX3 associates with JMJD3 at the enhancer region of Eomes, bringing its enhancer in close proximity to its promoter to drive its own expression. This DNA looping of Eomes allows for a self-activating loop, thereby, maintaining endoderm fate (Kartikasari et al., 2013) and preventing abnormal development. (C) Negative feedback of Noggin to BMP activity via Jmjd3 regulation.