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Stage-specific role of JMJD33 in lung development and function. (A) JMJD3 regulates lung development in a stage-dependent manner. H&E staining showing the stage-dependent effects of Jmjd3 deletion on lung architecture and its correlation with embryo viability. Bar = 200 μm, (B). A proposed model explaining how JMJD3 specifically upregulates SP-B expression by interacting with Nkx2.1 and Brg1 at the SP-B promoter.
