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. Author manuscript; available in PMC: 2015 Sep 9.
Published in final edited form as: Mol Pharm. 2015 Aug 7;12(9):3237–3249. doi: 10.1021/acs.molpharmaceut.5b00183

Table 2.

Total number of peptide-peptide, peptide-water and peptide-excipient adducts detected by LC-MS in solid- and solution-state Mb-SDA formulations without excipients, with raffinose and with Gdn HCl. The numbers represent the average number of adducts (± SD) from three LC-MS injections.

Type of Adducts Number of Adducts Detected
Mb-SDA Mb-SDA + Raffinose Mb-SDA + Gdn HCl
Solid Solution Solid Solution Solid Solution
Peptide-Peptide 44.7 ± 3.5 30.3 ± 0.6 50.7 ± 3.2 31.3 ± 1.2 105.0 ± 12.3 28.3 ± 2.1
Peptide-Water 42.7 ± 3.8 30.0 ± 1.7 11.3 ± 1.2 19.7 ± 1.2 74.3 ± 10.2 34.3 ± 1.5
Peptide-Excipient N/A N/A 11.3 ± 0.6 41.3 ± 0.6 N/A a N/A a
a

Peptide-excipient adducts for the Gdn HCl formulation could not be identified unambiguously by LC-MS and are not reported.