Skip to main content
. Author manuscript; available in PMC: 2015 Sep 9.
Published in final edited form as: Mol Pharm. 2015 Aug 7;12(9):3237–3249. doi: 10.1021/acs.molpharmaceut.5b00183

Table 5.

Crosslinking numbers for peptide-water adducts (X12*) values (± SD, n=3) for each lyophilized formulation.

Group X12* (± SD)
Control Raffinose Gdn HCl
1 0.3 ± 0.6 1.0 ± 0.0 2.0 ± 0.0
2 0.9 ± 0.2 0.4 ± 0.0 1.5 ± 0.2
3 0.4 ± 0.0 0.3 ± 0.1 1.4 ± 0.3
4 0.3 ± 0.1 0.0 ± 0.0 0.4 ± 0.1
5 3.3 ± 0.1 2.2 ± 0.5 2.9 ± 0.4
6 0.9 ± 0.1 0.4 ± 0.0 1.0 ± 0.4
7 0.3 ± 0.1 1.0 ± 0.0 1.1 ± 0.0
8 0.3 ± 0.3 0.2 ± 0.1 0.7 ± 0.1
Total (ΣX12*) 6.8 ± 0.9 5.6 ± 0.5 11.0 ± 1.0

Note: The moisture contents of the control, raffinose and Gdn HCl formulations were 1.03%, 1.92% and 0.04% (w/w).