Skip to main content
. Author manuscript; available in PMC: 2016 Sep 8.
Published in final edited form as: Mol Pharm. 2015 Aug 24;12(9):3250–3260. doi: 10.1021/acs.molpharmaceut.5b00216

Figure 2.

Figure 2

Dual-targeted AuNPs-Pc 4 accumulate rapidly in glioma cell lines expressing both biomarkers. (a) Time course uptake of AuNPs conjugates (500 nM) in U87 and LN229 cell lines. Pc 4 fluorescence was acquired at 670 nm. (b) Relative intensities of Pc 4 versus time (0–60 min) for U87 and LN229 cells after treatment with either 500 nM of (EGFpep+Tfpep)-AuNPs-Pc 4 or AuNPs-Pc 4. (c) Time course (0–24 h) uptake of single targeted AuNPs conjugates as compared to dual-targeted AuNPs in U87 cell line. (d) Quantification of Pc 4 accumulation over time measured as relative fluorescence.