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Pc 4-loaded dual-targeted AuNPs for differential in vivo detection of tumors. (a) Representative normalized (hotmap) images of fluorescence reconstruction showing the targeting of (EGFpep+Tfpep)-AuNPs-Pc 4 versus untargeted AuNPs-Pc 4 to orthotopic brain tumors after 1, 4, and 6 h post injection. (b) Graph of average Pc 4 fluorescence intensity signal in mice bearing orthotopic U87 tumors with (EGFpep+Tfpep)-AuNPs-Pc 4 or AuNPs-Pc 4.
