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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Autoimmun. 2015 Jul 14;63:47–58. doi: 10.1016/j.jaut.2015.07.002

Fig. 1. Type I and II interferon inducible genes (IFIGs) as well as type I and II interferon (IFN) scores in peripheral blood (PB) of Sjogren's syndrome (SS) patients and healthy controls (HC).

Fig. 1

A. Normalized relative mRNA expression of preferentially type I IFIGs in PB samples derived from 30 HC, 31 SS-non lymphoma and 13 SS-lymphoma patients. Transcript levels of the MX-1, IFIT-1 and IFI44 genes were lower in HC compared to both SS non-lymphoma (p-value: <0.0001 for all comparisons) and SS-lymphoma groups (p-values: <0.0001, 0.0004 and 0.0002, respectively). No statistically significant differences were detected between the SS subgroups. B. PB type I IFN score was found to be significantly higher in both SS subgroups compared to HC (p-values: <0.0001 for both comparisons), with no significant differences between SS subgroups. C. Normalized relative mRNA expression of the preferentially type II IFIGs GBP-1 and MIG-1 in PB from 30 HC, 31 SS-non lymphoma and 13 SS-lymphoma patients. Transcript levels of the GBP-1 and MIG-1 genes were lower in HC compared to both SS non-lymphoma (p-values: 0.001 and 0.008, respectively) and SS-lymphoma groups (p-values: 0.003 and 0.02, respectively), with no detectable differences between SS subgroups. D. PB type II IFN score was found to be significantly increased in both SS subgroups complicated or not by lymphoma compared to HC, p-values: 0.004 and 0.0005, respectively. (*p<0.05, ** p<0.01, *** p<0.001). RE: Relative expression.