Fig. 2. Only E-syt1 formed tethers regulate the Orai1-STIM1 complex.
Panel (a): Orai1 current was measured in the presence of STIM1 (black), STIM1+E-Syt1 (red) and in cells treated with siE-Syt1 (green). Panels (b, c): Orai1 current was measured in the presence of STIM1 (black), STIM1+E-Syt2 (red in b) or E-Syt3 (red in c). Note that only E-Syt1 increased SCDI and knockdown of E-Syt1 reduced SCDI. The results in panel (a) are reproduced from [31].