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A molecular model for collaborative recruitment of CBP/p300 KIX (purple) at CREs (blue) by CREB (green) and CRTC1-MAML2 (gold). The model is based on the structures of CREB bound to CRE (PDB: 1DH3),(30) the CREB binding domain of CRTC2 (PDB: 4HTM),(10) the MLL1-CBP KIX (PDB: 2AGH)(25) and CREB-CBP KIX (PDB: 1KDX)(5) complexes.
