Table II.
Likely CAMs for which single nucleotide polymorphisms are likely to provide partial or complete human “knockout” (79).
| gene | chr:bp | Ref | Alt | Af | frequency | ||
|---|---|---|---|---|---|---|---|
| EuAm | As | Eu | |||||
| CDH19 | 18:64235709 | C | A | 0 | 0.28 | 0 | 0 |
| CDHR2 | 5:175998270 | C | T | 0 | 0 | 0.2 | 0 |
| CEACAM1 | 19:43031354 | G | A | 0 | 0.28 | 0 | 0 |
| CLDN20 | 6:155597004 | G | A | 0 | 0 | 0.2 | 0.8 |
| CNTN6 | 3:1415319 | G | T | 0 | 0 | 0 | 0.1 |
| DSG4 | 18:28993525 | C | T | 0.4 | 0 | 0 | 0 |
| 18:28979436 | T | G | 0 | 0 | 0.2 | 0 | |
| 18:28993216 | C | T | 0 | 0 | 0 | 0.1 | |
| DSP | 6:7584223 | T | A | 0 | 0.28 | 0 | 0 |
| 6:7583371 | G | A | 0 | 0 | 0.2 | 0 | |
| EPHB1 | 3:134885826 | C | T | 0 | 0.28 | 0 | 0 |
| FAT1 | 4:187518227 | C | A | 0.2 | 0 | 0 | 0 |
| 4:187630007 | C | T | 0.2 | 0 | 0 | 0 | |
| FAT2 | 5:150923303 | G | A | 0 | 0.28 | 0 | 0 |
| ICAM3 | 19:10446525 | C | T | 0 | 0.28 | 0 | 0 |
| 19:10445374 | G | A | 0 | 0 | 0.2 | 0 | |
| ITGA10 | 1:145542272 | C | T | 0 | 0.28 | 0 | 0.1 |
| 1:145539790 | C | T | 0 | 0 | 0.2 | 0 | |
| 1:145533485 | C | T | 0 | 0 | 0 | 0.1 | |
| ITGA11 | 15:68641223 | C | A | 0 | 0 | 0 | 0.1 |
| ITGA7 | 12:56092316 | G | A | 0 | 0 | 0.2 | 0 |
| ITGAD | 16:31425869 | C | T | 0 | 0 | 0 | 0.1 |
| ITGB6 | 2:160994697 | C | A | 0 | 0.28 | 0 | 0 |
| 2:160993947 | C | A | 0.2 | 0 | 0 | 0 | |
| KIR2DL1 | 19:55286866 | C | G | 0 | 0 | 0 | 0.5 |
| 19:55331238 | C | T | 0 | 0 | 0.2 | 0 | |
| LAMA2 | 6:129475705 | A | T | 0 | 0 | 0.5 | 0 |
| 6:129636987 | C | T | 0 | 0 | 0 | 0.1 | |
| LAMC3 | 9:133954628 | C | T | 0.2 | 0 | 0 | 0 |
| LRRN3 | 7:110764535 | C | T | 0 | 0 | 0.2 | 0 |
| OLFM4 | 13:53617308 | C | T | 0 | 0 | 0 | 2.6 |
| 13:53624743 | T | A | 0 | 0 | 0.2 | 0 | |
| PCDH18 | 4:138449706 | G | A | 0 | 0.28 | 0 | 0 |
| PCDH7 | 4:30725762 | A | T | 0 | 0 | 0 | 0.1 |
| PCDHB1 | 5:140432438 | C | T | 0 | 0 | 0.2 | 0 |
| PCDHB4 | 5:140503823 | C | G | 0 | 0 | 0 | 0.3 |
| PCDHB7 | 5:140554309 | G | T | 0 | 1.66 | 0.2 | 0.3 |
| 5:140553499 | G | T | 0.4 | 0 | 0 | 0 | |
| PCDHB8 | 5:140558148 | T | G | 0.2 | 0 | 0 | 0 |
| 5:140558623 | C | T | 0 | 0 | 0.2 | 0 | |
| 5:140559627 | C | A | 0 | 0 | 0.2 | 0 | |
| PCDHGA10 | 5:140794929 | C | T | 0.2 | 1.1 | 0 | 0.4 |
| PCDHGA8 | 5:140773284 | C | G | 0 | 0 | 0 | 0.1 |
| PCDHGA9 | 5:140783659 | C | T | 0 | 0 | 0.5 | 0 |
| PCDHGC5 | 5:140869257 | C | T | 0.2 | 0 | 0 | 0 |
| 5:140870361 | C | T | 0 | 0 | 0 | 0.1 | |
| 5:140870415 | C | T | 0 | 0 | 0 | 0.1 | |
| PTPRH | 19:55697711 | G | A | 0 | 0.28 | 0 | 0.5 |
| PTPRU | 1:29650188 | G | A | 0.2 | 0 | 0 | 0 |
| ROBO2 | 3:77611841 | C | A | 0.2 | 0 | 0 | 0 |
| SDK1 | 7:4213906 | C | A | 0 | 0 | 0.2 | 0 |
| SELL | 1:169676573 | C | T | 0.2 | 0 | 0 | 0 |
| SEMA5A | 5:9197325 | G | T | 0 | 0 | 0.2 | 0 |
| SPAM1 | 7:123599667 | G | A | 0 | 0 | 0 | 0.1 |
| THBS4 | 5:79372855 | C | T | 0.2 | 0 | 0 | 0 |
| 5:79366570 | C | T | 0 | 0 | 0 | 0.1 | |
| TNN | 1:175052986 | C | T | 0 | 0 | 0.2 | 0 |
Columns list: gene symbol, chromosome and basepair of variant, major/reference allele, minor/mutant allele, and minor allele frequencies in 1000 genomes data from African, US individuals of European ancestry, Asian and European samples. Note that many CAM genes are also sites for copy number and other variation that can also provide knockouts.