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. 2015 Aug 24;6:353–371. doi: 10.1016/j.redox.2015.07.017

Fig. 10.

Fig. 10

Synergistic interaction between the NOD inhibitor cyanidin and catalase inhibitors. (A) 12,500 MKN-45 cells received no addition (control) or the indicated concentrations of cyanidin, antibody directed towards the EGF receptor (aEGFR), neutralizing antibodies directed against human catalase (aCAT) or salicylic acid (SA). The percentages of apoptotic cells obtained by sole application of these compounds was determined after 6.5 h. (B) 12,500 MKN-45 cells received no addition (control) or 0.15 ng/ml cyanidin, 1 ng/ml aEGFR, 1 ng/ml aCAT, 0.1 µg/ml SA applied alone or 0.15 ng/ml cyanidin combined with either 1 ng/ml aEGFR, 1 ng/ml aCAT, 0.1 µg/ml SA. The percentages of apoptotic cells were determined after 6 h. Statistical analysis: (A) Apoptosis induction by cyaniding, aCAT and salicylic acid was highly significant (p<0.001). (B) The synergistic effect between cyaniding and aCAT and cyaniding and salicylic acid was highly significant (p<0.001).