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. 2015 Aug 24;6:353–371. doi: 10.1016/j.redox.2015.07.017

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 15 — Singlet oxygen-dependent and –independent activity of NO-acetyl salicylic acid. 12,500 MKN-45 cells were treated with increasing concentrations of acetyl salicylic acid (ASA) (A) or NO-acetyl salicylic acid (NCX 4040) (B) in the absence and presence of 2 mM histidine (HIS) or 100 µM AEBSF. The percentages of apoptotic cells were determined after 3.5 h. Statistical analysis: (A) Apoptosis induction by acetylsalicylic acid (1-40 µg/ml) as well as its inhibition by histidine were highly significant (p<0.001). AEBSF caused no significant inhibitory effect. (B) The shift of the concentration-response curve of NCX 4040 compared to acetylsalicylic acid (A) was highly significant, as were the effects of histidine and AEBSF (p<0.001).