Table 1.

Protective Efficacy Against Lethal Challenge by Mouse-Adapted Ebola Virus

Group	Immunization Regimen	Animals With Weight Loss, No.a (n = 5)	Animal With Illness, No.b (n = 5)	Animals That Survived, No.c (n = 5)
1	sGP DNA (2 doses)	5	5	1
2	sGP DNA (3 doses)	1	5	5
3	sGP DNA (2 doses) + GP DNA (1 dose)	2	5	5
4	GP DNA (2 doses)	2	4	5
5	GP DNA (3 doses)	0	0	5
6	GP DNA (2 doses) + sGP DNA (1 dose)	0	0	5
7	pCAGGS (3 doses)	5	5	0

Abbreviations: GP, Ebola virus glycoprotein; sGP, truncated Ebola virus glycoprotein isoform.

^a Weight changes were monitored daily after challenge. Weight loss was defined a decrease of >5% in body weight from day 0.

^b Mice were monitored after challenge for disease signs, such as ruffled fur or hunched back, or lack of activity. They were considered to be ill if any of these symptoms were observed.

^c Mice that exhibited severe disease symptoms or a body weight loss of >25% from day 0 were euthanized in accordance with institutional animal care and use committee guidelines.