Figure 4.

Passive transfer of serum from infected hamsters protects CD4-depleted hamsters from disease. Twelve days after inoculation serum from either nondepleted or CD4-depleted hamsters that were inoculated with Ebola virus, strain Mayinga (EBOV-May) were transferred to CD4-depleted hamsters on days 4 and 7 after inoculation with EBOV-May. As a control, phosphate buffered saline (PBS) was administered to a group of hamsters at these same time points. Hamsters that received antibodies from nondepleted donors showed no clinical disease. Hamsters given PBS or serum from CD4-depleted donors became clinically ill, and all but 1 required euthanasia.