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MBX2254 and MBX2270 cause cholesterol accumulation in late endosomes/lysosomes. A549 cells were treated for overnight with MBX2254, MBX2270, E64, or compound 3.47 at concentrations described in “Methods” section. Cells were then fixed, stained with filipin, and imaged with a fluorescence microscope. Representative images are shown. Each compound was tested ≥3 times.
