Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Aug 4;5(8):e612. doi: 10.1038/tp.2015.102

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

The ratio of β1:β2_ALL, β1:β2_50 kDa and β2_52 kDa:β2_48 kDa GABA_AR subunit expression is increased in the SYN fraction in schizophrenia. Western blot analysis of the ratios of β1 and β2 GABA_AR subunit isoform expression in the SYN fraction in schizophrenia and comparison subjects. (a) The ratio of β2_52 kDa:β2_48 kDa GABA_AR subunit expression is increased in schizophrenia, with no difference between groups for the ratio of β2_52 kDa:β2_50 kDa or β2_50 kDa:β2_48 kDa GABA_AR subunit expression in the SYN fraction. (b) The ratio of β1:β2_ALL and β1:β2_50 kDa GABA_AR subunit expression is decreased in the SYN fraction in schizophrenia. Data are expressed as a ratio of the signal intensity of protein targets in the SYN fraction normalized to VCP as a loading control and gephyrin as an inhibitory synaptic marker relative to the VCP-normalized signal intensity of the same targets in total homogenate for each subject; data are means±s.e.m. *P<0.05. COMP, comparison subject; GABA_AR, γ-aminobutyric acid type A receptor; SCZ, schizophrenia; SYN, synapse; VCP, valosin-containing protein.