Table 3. Areas of activation associated with correct recognition effect (RC>New) in the 1-back memory load in TD and ASD children.
Within-group recognition effects |
Group differences | ||||||
---|---|---|---|---|---|---|---|
Time windows | Brain area | Pseudo z-values | MNI coordinates | ||||
TD children | |||||||
375–425 | R | MTG | 0.75 | 44 | −7 | −18 | |
R | Precentral gyrus | 0.66 | 44 | 8 | 27 | ||
400–450 | R | Hippocampus | 0.87 | 42 | −12 | −18 | TD>ASD |
R | Precentral gyrus | 0.57 | 49 | 8 | 27 | ||
R | mPFC | 0.54 | 19 | 48 | 2 | ||
425–475 | R | Hippocampus | 0.74 | 39 | −12 | −18 | TD>ASD |
450–500 | R | Hippocampus | 0.52 | 44 | −12 | −18 | |
R | MCC | 0.52 | 4 | −27 | 42 | TD>ASD | |
R | OFG | 0.62 | 9 | 28 | −23 | ||
L | ACC | 0.73 | −1 | 38 | 22 | TD>ASD | |
475–525 | R | ACC | 0.72 | 4 | 38 | 7 | |
525–575 | R | OFG | 0.47 | 24 | 23 | −18 | |
ASD children | |||||||
200–250 | L | dlPFC | 0.52 | −26 | 18 | 37 | ASD>TD |
225–275 | L | dlPFC | 0.64 | −21 | 23 | 37 | ASD>TD |
400–450 | R | mPFC | 0.89 | 29 | 53 | 7 | |
425–475 | L | Insula | 0.84 | −31 | −22 | 22 | ASD>TD |
R | Insula | 0.83 | 34 | 18 | 7 | ASD>TD | |
450–500 | R | Insula | 0.73 | 39 | −2 | 12 | ASD>TD |
R | Hippocampus | 0.73 | 29 | −17 | −13 | ||
R | mPFC | 0.78 | 29 | 53 | 7 | ||
500–550 | L | OFG | 0.61 | −31 | 43 | −3 | |
L | ACC | 0.61 | −1 | 43 | 22 | ||
525–575 | R | MCC | 0.66 | 14 | −27 | 47 |
Abbreviations: ACC, anterior cingulate cortex; ASD, autism spectrum disorder; dlPFC, dorso-lateral prefrontal cortex; L, left; MCC, middle cingulated cortex; MNI, Montreal Neurological Institute; mPFC, medial prefrontal cortex; MTG, medial temporal gyrus; OFG, orbito-frontal gyrus; PCG, precentral gyrus; R, right; RC, repeat–correct' trial; TD, typically developing.
Note: Statistical significance was set for the significant voxels of activation at P<0.05, corrected for multiple comparisons in the whole source–space volume for within-group comparisons (recognition effect in each group; RC vs New stimuli) and at P<0.005 uncorrected for between-group comparisons (recognition contrast (RC–New stimuli) by group, highlighted in bold).