Table 3. Association between T2D predisposing SNPs, genotype score and major depressive disorder under the additive, dominant and recessive models.

Gene	SNP		Additive			Dominant			Recessive
		Risk allele	Odds ratio	95% Confidence interval	P-value	Odds ratio	95% Confidence interval	P-value	Odds ratio	95% Confidence interval	P-value
GCKR	rs1260326	C	0.951	0.897–1.008	0.090	0.912	0.816–1.019	0.105	0.950	0.874–1.032	0.226
IRS1	rs2943634	C	1.036	0.975–1.100	0.258	0.991	0.872–1.125	0.888	1.068	0.985–1.158	0.108
PPARγ2	rs1801282	C	1.029	0.940–1.127	0.539	0.828	0.590–1.164	0.277	1.051	0.951–1.161	0.330
IGF2BP2	rs1470579	C	1.039	0.979–1.102	0.211	1.040	0.958–1.129	0.351	1.071	0.952–1.205	0.254
WFS1	rs1801214	T	1.011	0.953–1.072	0.714	0.972	0.864–1.094	0.642	1.034	0.954–1.121	0.412
CDKAL1	rs7754840	C	1.002	0.945–1.063	0.943	1.011	0.933–1.096	0.785	0.983	0.870–1.112	0.790
GCK	rs1799884	A	1.008	0.939–1.082	0.822	0.996	0.916–1.084	0.934	1.092	0.892–1.337	0.392
SLC30A8	rs13266634	C	0.975	0.915–1.039	0.429	0.909	0.783–1.054	0.207	0.986	0.910–1.069	0.741
CDKN2A/B	rs2383208	A	0.997	0.927–1.073	0.937	1.075	0.858–1.346	0.531	0.986	0.905–1.073	0.738
HHEX	rs5015480	C	0.992	0.938–1.050	0.792	1.073	0.970–1.186	0.170	0.933	0.856–1.017	0.113
TCF7L2	rs7903146	T	0.989	0.931–1.051	0.722	0.997	0.921–1.079	0.940	0.954	0.832–1.095	0.503
KCNQI	Rs231362	C	1.029	0.972–1.090	0.325	0.959	0.864–1.065	0.437	1.092	1.005–1.188	0.039
KCNQI	rs2283228	A	0.950	0.870–1.036	0.245	0.760	0.579–0.998	0.048	0.968	0.876–1.070	0.527
KCNJ11	rs5219	T	0.987	0.930–1.047	0.671	0.979	0.901–1.063	0.607	0.993	0.882–1.118	0.912
MTNR1B	rs10830963	G	1.003	0.942–1.068	0.932	1.002	0.924–1.087	0.964	1.009	0.874–1.164	0.908
HNF1B	rs4430796	G	0.967	0.914–1.023	0.246	0.978	0.895–1.069	0.623	0.932	0.846–1.026	0.151
BCL2	Rs12454712	T	1.013	0.956–1.074	0.656	0.976	0.873–1.090	0.664	1.040	0.959–1.129	0.342
GATAD2A	rs16996148	T	0.953	0.862–1.054	0.350	0.958	0.859–1.069	0.444	0.812	0.528–1.250	0.344
GIPR	rs8108269	G	1.033	0.974–1.096	0.281	1.014	0.936–1.098	0.735	1.113	0.986–1.256	0.083
HNF4A	rs1884614	T	1.042	0.977–1.112	0.211	1.054	0.971–1.145	0.211	1.050	0.901–1.224	0.531
Gene score			1.002	0.987–1.016	0.833	—	—	—	—	—	—

Abbreviations: BMI, body mass index; SNP, single-nucleotide polymorphism; T2D, type 2 diabetes.

All P-values adjusted for sex, age, ethnicity and BMI.