Table 1. Baseline characteristics by treatment status in all depressive patients after ACS (n=446).
|
EsDEPACS trial (N=300) |
K-DEPACS cohort (N=146) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Esc.+Statin | Esc. only | Statin only | Placebo only | P-value | Statin use | Standard treatment | P-value | |
| N (%) | N (%) | N (%) | N (%) | |||||
| 116 (38.7) | 33 (11.0) | 110 (36.7) | 41 (13.7) | 97 (66.4) | 49 (33.6) | |||
| Demographic characteristics | ||||||||
| Age, mean (s.d.) years | 60.3 (10.8) | 58.9 (12.9) | 60.4 (10.8) | 59.3 (10.0) | 0.855 | 57.8 (11.8) | 59.3 (11.2) | 0.458 |
| Gender, N (%) men | 66 (56.9) | 22 (66.7) | 63 (57.3) | 30 (73.2) | 0.223 | 59 (60.8) | 25 (51.0) | 0.258 |
| Education, mean (s.d.) years | 9.2 (4.3) | 10.1 (3.7) | 9.0 (4.2) | 9.6 (3.8) | 0.616 | 8.9 (5.4) | 9.0 (4.5) | 0.891 |
| Depression characteristics | ||||||||
| HAM-D, mean (s.d.) score | 15.6 (4.7) | 16.8 (5.1) | 15.9 (5.0) | 14.9 (4.1) | 0.374 | 10.7 (3.5) | 11.3 (3.4) | 0.327 |
| BDI, mean (s.d.) score | 18.5 (8.3) | 20.0 (8.5) | 19.2 (7.8) | 19.1 (7.3) | 0.782 | 14.0 (7.2) | 14.5 (5.5) | 0.650 |
| DSM-IV diagnosis, N (%) | ||||||||
| Major depressive disorder | 63 (54.3) | 22 (66.7) | 59 (53.6) | 25 (61.0) | 0.511 | 18 (18.6) | 15 (30.6) | 0.100 |
| Cardiac risk factors, N (%) | ||||||||
| Hypertension | 64 (55.2) | 26 (78.8) | 70 (63.6) | 24 (58.5) | 0.091 | 43 (44.3) | 25 (51.0) | 0.444 |
| Diabetes mellitus | 33 (28.4) | 11 (33.3) | 31 (28.2) | 10 (24.4) | 0.868 | 18 (18.6) | 10 (20.4) | 0.788 |
| Hypercholesterolaemia | 61 (52.6) | 12 (36.4) | 54 (49.1) | 17 (41.5) | 0.318 | 57 (58.8) | 21 (42.9) | 0.069 |
| Obesity | 46 (39.7) | 13 (39.4) | 55 (50.0) | 10 (24.4) | 0.038 | 42 (43.3) | 18 (36.7) | 0.447 |
| Current smoker | 33 (28.4) | 10 (30.3) | 28 (25.5) | 14 (34.1) | 0.754 | 34 (35.1) | 10 (20.4) | 0.069 |
| Current cardiac status | ||||||||
| ACS diagnosis, N (%) | ||||||||
| Myocardial infarction | 77 (66.4) | 15 (45.5) | 70 (63.6) | 22 (53.7) | 0.111 | 31 (32.0) | 21 (42.9) | 0.194 |
| Killip class >1, N (%) | 20 (17.2) | 4 (12.1) | 28 (25.5) | 7 (17.1) | 0.248 | 18 (18.6) | 10 (20.4) | 0.788 |
| LVEF, mean (s.d.) % | 60.7 (10.6) | 59.4 (12.3) | 60.4 (11.4) | 62.3 (12.0) | 0.561 | 59.1 (12.2) | 62.0 (13.1) | 0.190 |
| Troponin I, mean (s.d.) mg dl−1 | 10.0 (9.0) | 8.6 (6.4) | 10.2 (8.6) | 8.2 (5.7) | 0.481 | 11.3 (17.4) | 6.2 (12.2) | 0.043 |
| CK-MB, mean (s.d.) mg dl−1 | 17.5 (23.0) | 16.1 (18.3) | 17.0 (21.7) | 14.5 (18.3) | 0.888 | 20.1 (47.4) | 15.8 (29.8) | 0.570 |
| T-cholesterol | 184.3 (38.0) | 171.3 (42.6) | 188.6 (39.8) | 175.4 (43.8) | 0.090 | 195.4 (38.4) | 180.6 (47.8) | 0.045 |
| CRP | 1.1 (0.9) | 1.2 (1.1) | 1.4 (3.2) | 0.7 (0.3) | 0.303 | 1.0 (1.1) | 1.2 (2.7) | 0.480 |
Abbreviations: ACS, acute coronary syndrome; BDI, Beck Depression Inventory; CK-MB, creatine kinase-MB; CRP, C-reactive protein; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders 4th edition; Esc., escitalopram; EsDEPACS, the Escitalopram for Depression in Acute Coronary Syndrome trial; HAM-D, Hamilton Depression Rating Scale; K-DEPACS, the Korean Depression in Acute Coronary Syndrome study; LVEF, left ventricular ejection fraction; T-cholesterol, total cholesterol.
Values in bold show statistical significance (P-value=0.05).