Table 1.
Psychotic CSF-collective | Number of patients |
---|---|
(1) Schizophreniform syndrome group | 132 |
Schizophrenia | 104 |
Delusional disorder | 4 |
Acute polymorphic psychotic disorder | 18 |
Schizotypal disorder | 2 |
Substance-induced psychosis | 4 |
(2) Schizoaffective syndrome group | 43 |
(3) Psychotic syndromes in the context of other disorders | 5* |
Diagnostic measurements | Number of samples |
CSF basic diagnostics (white blood cell count, protein concentration, albumin quotient, and intrathecal immunoglobulin synthesis) | 180 |
Intracellular synaptic antigens (GAD, amphiphysin) and intracellular onconeural antigens (Yo, Hu, Ri, Cv2/CRMP5, Ma1, Ma2, SOX1) | 142 |
Antibodies against neuronal cell surface antigens (NMDAR, AMPA-1/2-R, GABA-B-R, VGKC-complex) | 96 (Freiburg) + 29**(Weatherall Institute of Molecular Medicine at the John Radcliffe Hospital [Oxford, United Kingdom]) |
Thyroid-antibodies | |
Anti-thyroid peroxidase antibodies | 73 |
Anti-thyroglobulin antibodies | 70 |
Thyroid-stimulating hormone receptor antibodies | 33 |
Electroencephalography data sets | 175 |
Magnetic resonance imaging data sets | 152 |
Psychotic syndrome group in the context of other disorders is consisting of (1) Morbus Wilson, (2) presumed viral encephalitis, (3) prodromal symptoms of derealization and depersonalization, (4) prodromal symptoms within the framework of autistic spectrum disorder, and (5) acute state of confusion with psychotic symptoms.
Only NMDAR and VGKC-complex antibodies. GAD, glutamic acid decarboxylase; Yo/ Hu/ Ri, abbreviations of first patients' name; Cv2/CRMP5, anti-collapsin response-mediator protein; Ma1/ Ma2, 37 and 40 kDa neuronal proteins; SOX1, sry-like high-mobility group box 1; NMDAR, N-methyl-D-aspartat-receptor; AMPA-1/2-R, α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor; GABA-B-R, γ-aminobutyric acid receptor; VGKC-complex, voltage gated potassium channels complex.