Table 1.
Summary of Bacopa monniera treatment effects on serotonergic system and its associated pathway.
| Neurotransmitters | Effects | Genes (mRNA) |
Effects | Genes (Protein) |
Effects | References |
|---|---|---|---|---|---|---|
| Serotonin | ↑ | Tph2 | ↑ | [35] | ||
| SERT | ↑ | |||||
|
| ||||||
| Serotonin Dopamine Acetylcholine GABA Glutamate |
↑ ↓ ↑ ↑ ↑ |
5-HT1 A | — | |||
| 5-HT2 A | ↑ | |||||
| 5-HT3 A | ↑ | |||||
| 5-HT4 | — | [41] | ||||
| 5-HT5 | — | |||||
| 5-HT6 | — | |||||
| 5-HT7 | ↓ | |||||
|
| ||||||
| Nrf2 | ↑ | SYP SYT t-αCaMKII p-αCaMKII PSD-95 |
↑ ↑ ↑ ↑ ↑ |
[43] | ||
|
| ||||||
|
Dicer
Ago2 miR-124 Creb1 |
↓ ↓ ↓ ↑ |
DICER AGO2 t-CREB1/2 p-CREB1/2 |
↓ ↓ ↑ ↑ |
[39] | ||
|
| ||||||
|
Bdnf
PP1α |
↑ ↓ |
t-ERK1/2 | ↑ | |||
| p-ERK1/2 | ↑ | |||||
| t-CREB1/2 | ↑ | |||||
| p-CREB1/2 | ↑ | |||||
| Ac-H3 | ↑ | [42] | ||||
| Ac-H4 | ↑ | |||||
| HDAC1 | ↓ | |||||
| HDAC2 | ↓ | |||||
| p300 | ↑ | |||||
| PP2A | ↓ | |||||
↓: decrease; ↑: increase.