Table 1.

United States decision-making criteria used to assess aspects of the condition for newborn screening (19).

Criteria	Categories	Score
Incidence of condition	>1:5,000	100
	>1:25,000	75
	>1:50,000	50
	>1:75,000	25
	<1:100,000	0
Signs and symptoms clinically identifiable in the first 48 h	Never	100
	<25% cases	75
	<50% cases	50
	<75% cases	25
	Always	0
Burden of disease (natural history if untreated)	Profound	50
	Severe	100
	Moderate	75
	Mild	25
	Minimal	0

The US decision-making framework includes 14 criteria against which a condition is assessed. The following table is an example of three of the criteria. Conditions are scored against the criteria by stakeholders, with data being validated by experts. The mean score given for each criterion by stakeholders is then summed. The maximum possible score for a condition across all 14 criteria is 2100. Any score above 1200 is considered appropriate for inclusion on the recommended core panel for screening.