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. 2015 Sep 10;2(3):ofv116. doi: 10.1093/ofid/ofv116

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© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 5. — Virulence assays are shown. (A) Cumulative mortality of mice given injections of 4 × 10⁵ cells from bmt1Δ, bmt1Δ/BMT1, and bmt1Δ bmt2Δ bmt5Δ mutants and their reference strain, CAI-4. Difference between CAI-4 and bmt1Δ or bmt1Δ bmt2Δ bmt5Δ mutants were significant (P < .05). Fungal burdens of different Candida albicans strains in the spleen, kidney, and liver of BALB/c (B), C57BL/6 (C), and Gal3^−/− (D) mice, 3 days postintraperitoneal infection. Mice received intraperitoneal injection of 5 × 10⁷ CAI-4, bmt1Δ, and bmt1Δ bmt2Δ bmt5Δ cells. The results shown are from 3 independent experiments. *, P < .05; **, P < .01. All the mutants and their reference strains are Ura⁺ with CIp10 integrated in the same RPS1 allele.