Table 2. Metabolite identity and excretion.

Metabolite	Proposed transformation	Site of detection	Fraction of dose in feces 0 - 120 h, %	Fraction of dose in urine 0 - 24 h, %
Naloxegol	Unchanged	P, F, U	16.2	9.9
MX1	Not available	F	2.2	–
MX2	Not available	U	–	1.8
M13	Partial loss of PEG	P, F, U	4.5	1.1
M12	Partial loss of PEG and oxidation	F, U	9.1	0.4
M7	Partial loss of PEG	P, U	–	0.7
M10	Partial loss of PEG and oxidation	P, F, U	10.9	1.5
M1	Dealkylation	P, F	13.7	–
M4	Partial loss of PEG and oxidation	F	3.8	–
Fraction of dose			60.4	15.4

F = feces; MX = uncharacterized metabolite; P = plasma; PEG = polyethylene glycol; U = urine.