Table 3. Summary of metabolite profile data in plasma from healthy male volunteers after oral administration of 27 mg (3.43 MBq) naloxegol.
| Metabolite | Fraction of total peak area in plasma, %a | |||||
|---|---|---|---|---|---|---|
| Rt b | Rt, min | 0.5 hoursc | 2 hours | 4 hours | 6 hours | |
| Naloxegol | 1.0 | 23.9 | 100 | 75 | 64 | 100 |
| M13 | 0.79 | 19.0 | ND | 4.7 | 10 | ND |
| M7 | 0.82 | 19.6 | ND | 6.3 | 8.2 | ND |
| M10 | 0.84 | 20.2 | ND | 9.5 | 12 | ND |
| M1 | 0.90 | 21.5 | ND | 4.8 | 5.5 | ND |
ND = not detected (signal-to-noise ratio < 3 in the radiochromatogram); Rt = retention time. aPercentage of the total peak area in the radiochromatograms. bRelative to parent, calculated as Rt metabolite/Rt naloxegol. cCollection time after dosing.