Figure 10.

On-chip synthesis of RNA microarrays. (a) Schematic of on-chip RNA microarray synthesis. RNA aptamers are transcribed from a dsDNA template on a generator element and then captured on adjacent detector elements. (b) SPRI difference images of a two-component aptamer microarray after 10 min of exposure to solutions containing 40 nM VEGF and 25 nM thrombin. The diagram of the microarray layout shows the four different components of the microarray: generator elements, detector elements for VEGF and thrombin, and control elements that are labeled G, D1, D2, and C2, respectively.