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Changes in the interhelical interaction in the neighborhood of the mutations F358A7.42/V360A7.44. (A) The direct and indirect hydrogen bond interactions centered on the F358A7.42/V360A7.44 region of NTSR1-GW5. The water molecule located between N821.50 and N3657.49 has been observed in 59% of the snapshots in the MD simulation ensemble. (B) Corresponding conformation of the wild type NTSR1.
