Table 2. Association between different polymorphisms and recurrence-free survival of patients.
Epirubicin |
MMC |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Recurrence | All patients | MST * | Log-rank P | Adjusted HR (95% CI) | Recurrence | All patients | MST * | Log-rank P | Adjusted HR (95% CI) | |
GSTP1 rs1695 | ||||||||||
AA | 22 | 78 | 76.7 | 0.002 | 1.00 (reference) | 16 | 61 | 64.4 | 0.408 | 1.00 (reference) |
AG | 26 | 46 | 40.4 | 3.29 (1.63–6.63) | 23 | 51 | 52.6 | 0.63 (0.05–7.46) | ||
GG | 2 | 6 | 23.3 | 5.18 (1.05–25.62) | 1 | 2 | 62.5 | 1.56 (0.80–3.07) | ||
AA | 22 | 78 | 76.7 | 0.001 | 1.00 (reference) | 16 | 61 | 64.4 | 0.218 | 1.00 (reference) |
AG+GG | 28 | 52 | 40.7 | 3.47 (1.75–6.89) | 24 | 53 | 53.9 | 1.54 (0.79–3.01) | ||
GSTO1 rs4925 | ||||||||||
CC | 29 | 82 | 67.4 | 0.019 | 1.00 (reference) | 26 | 68 | 55.1 | 0.231 | 1.00 (reference) |
AC | 15 | 40 | 49.0 | 1.89 (0.94–3.83) | 6 | 30 | 74.5 | 0.34 (0.11–1.09) | ||
AA | 6 | 8 | 28.2 | 3.23 (1.16-8.94) | 8 | 16 | 45.3 | 1.12 (0.38–3.33) | ||
CC | 29 | 82 | 67.4 | 0.042 | 1.00 (reference) | 26 | 68 | 55.1 | 0.404 | 1.00 (reference) |
AC+AA | 21 | 48 | 43.8 | 1.96 (1.05–3.70) | 14 | 46 | 62.8 | 1.20 (0.60–2.44) | ||
GSTO2 rs156697 | ||||||||||
CC | 8 | 15 | 35.4 | 0.170 | 1.00 (reference) | 9 | 21 | 51.9 | 0.550 | 1.00 (reference) |
CT | 16 | 50 | 51.4 | 0.88 (0.31–2.51) | 9 | 38 | 63.2 | 0.75 (0.22–2.62) | ||
TT | 26 | 65 | 67.7 | 0.51 (0.22–1.22) | 22 | 55 | 55.3 | 1.12 (0.48–2.63) | ||
CC | 8 | 15 | 35.4 | 0.071 | 1.00 (reference) | 9 | 21 | 51.9 | 0.778 | 1.00 (reference) |
CT+TT | 42 | 115 | 64.3 | 0.56 (0.25–1.26) | 31 | 93 | 59.9 | 0.94 (0.42–2.14) | ||
ABCB1 rs3747802 | ||||||||||
TT | 48 | 126 | 28.1 | 0.580 | 1.00 (reference) | 38 | 111 | 28.0 | 0.105 | 1.00 (reference) |
TC | 2 | 3 | 71.3 | 0.33 (0.05–1.99) | 2 | 2 | 22.0 | 4.81 (0.99–23.50) | ||
CC | 0 | 1 | 21.0 | 0.00 | 0 | 1 | 8.0 | 0.00 | ||
ABCB1 rs3213619 | ||||||||||
TT | 47 | 114 | 29.1 | 0.335 | 1.00 (reference) | 36 | 103 | 25.8 | 0.323 | 1.00 (reference) |
TC | 3 | 9 | 32.7 | 0.91 (0.27–3.09) | 3 | 6 | 31.2 | 0.46 (0.06–3.75) | ||
CC | 0 | 7 | 23.7 | 0.00 | 1 | 5 | 64.0 | 1.17 (0.33–4.17) |
*Mean survival time was defined as the mean time before recurrence.