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. 2015 Sep 10;5:13969. doi: 10.1038/srep13969

Table 2. Expression patterns of 20 featured gene clusters in inbR-overexpressed and INH induced strains.

No. BCG ORF Log2(FC)*
        
inbR over-expressed INH induced MTB ORF Gene Function Peaks**
1 BCG_0079c 1.01 1.24 Rv0048c   hypothetical protein In
2 BCG_0086 1.91 2.14 Rv0055 rpsR 30S ribosomal protein S18 Up
  BCG_0087 1.52 1.53 Rv0056 rplI 50S ribosomal protein L9  
3 BCG_0114 −1.89 −1.56 Rv0081   transcriptional regulatory protein Up
  BCG_0115 −1.36 −1.36 Rv0082   oxidoreductase  
  BCG_0116 −1.69 −1.25 Rv0083   oxidoreductase  
  BCG_0117 −1.09   Rv0084 hycD formate hydrogenlyase hycD (FHL)  
  BCG_0118 −1.03   Rv0085 hycP hydrogenase hycP  
4 BCG_0313c 7.55   Rv0275c   TetR family transcriptional regulator Up
5 BCG_0380 1.59 3.65 Rv0341 iniB isoniazid inducible gene protein iniB  
  BCG_0381 2.70 5.41 Rv0342 iniA isoniazid inducible gene protein iniA  
  BCG_0382 1.34 4.04 Rv0343 iniC isoniazid inducible gene protein iniC Dn
6 BCG_0479 5.50 1.90 Rv0440 groEL chaperonin GroEL Up
7 BCG_0741 −1.94 −1.36 Rv0692   hypothetical protein  
  BCG_0742 −1.84 −2.06 Rv0693 pqqE coenzyme PQQ synthesis protein E pqqE  
  BCG_0743 −2.18 −2.25 Rv0694 lldD1 L-lactate dehydrogenase (cytochrome) lldD1 NA
  BCG_0744 −1.09 −1.25 Rv0695   hypothetical protein  
  BCG_0745 −1.25 −1.43 Rv0696   membrane sugar transferase  
8 BCG_0755 1.24 1.42 Rv0705 rpsS 30S ribosomal protein S19  
  BCG_0756 1.31 1.12 Rv0706 rplV 50S ribosomal protein L22  
  BCG_0757 1.60 1.72 Rv0707 rpsC 30S ribosomal protein S3  
  BCG_0758 1.60 1.83 Rv0708 rplP 50S ribosomal protein L16  
  BCG_0759 1.12 1.30 Rv0709 rpmC 50S ribosomal protein L29 Up
  BCG_0760 1.79 1.94 Rv0710 rpsQ 30S ribosomal protein S17  
9 BCG_0772 1.64 1.52 Rv0722 rpmD 50S ribosomal protein L30 NA
  BCG_0773 1.17   Rv0723 rplO 50S ribosomal protein L15  
10 BCG_1025c −1.22 −2.25 Rv0971c echA7 enoyl-CoA hydratase  
  BCG_1026c −1.64 −2.74 Rv0972c fadE12 acyl-CoA dehydrogenase fadE12  
  BCG_1027c −1.15 −2.06 Rv0973c accA2 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA2 Up
  BCG_1028c −1.00 −2.47 Rv0974c accD2 acetyl-/propionyl-coa carboxylase subunit beta accD2  
11 BCG_1191 −6.64 −1.40 Rv1130   hypothetical protein  
  BCG_1192 −5.64 −1.51 Rv1131 gltA1 citrate synthase NA
  BCG_1193 −2.00 −1.36 Rv1132   hypothetical protein  
12 BCG_1214c 1.38 1.06 Rv1153c omt O-methyltransferase omt NA
13 BCG_1223 −1.69 −2.32 Rv1161 narG respiratory nitrate reductase (alpha chain) narG  
  BCG_1224 −1.12 −1.64 Rv1162 narH respiratory nitrate reductase subunit beta narH Up
  BCG_1225 −1.06 −1.22 Rv1163 narJ respiratory nitrate reductase (delta chain) narJ  
14 BCG_1249   −1.06   Rv1187 rocA  
  BCG_1250   −1.40 Rv1188     Up
  BCG_1251 −2.06 −2.25 Rv1189 sigI RNA polymerase sigma factor SigI  
15 BCG_1692 2.18   Rv1653 argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase  
  BCG_1693 2.34   Rv1654 argB acetylglutamate kinase  
  BCG_1694 2.34   Rv1655 argD acetylornithine aminotransferase NA
  BCG_1695 1.32   Rv1656 argF ornithine carbamoyltransferase  
  BCG_1696 1.13   Rv1657 argR arginine repressor  
16 BCG_2047c −1.94 −2.94 Rv2028c   hypothetical protein NA
  BCG_2048c −1.84 −2.64 Rv2029c pfkB phosphofructokinase pfkB  
  BCG_2049c −1.18 −2.18 Rv2030c   hypothetical protein  
  BCG_2050c −1.84 −1.94 Rv2031c hspX heat shock protein hspX  
17 BCG_2264 1.04 1.94 Rv2247 accD6 acetyl/propionyl CoA carboxylase subunit beta NA
  BCG_2265 1.71 2.98 Rv2248   hypothetical protein  
  BCG_2266 1.79 3.04 Rv2248   hypothetical protein  
  BCG_2267c 2.28   Rv2249c glpD1 glycerol-3-phosphate dehydrogenase glpd1  
  BCG_2268c 2.11   Rv2250c   transcriptional regulatory protein  
  BCG_2269 2.16   Rv2251   flavoprotein  
  BCG_2270 2.20   Rv2252   diacylglycerol kinase  
  BCG_2271 −1.36 −1.47 Rv2253   hypothetical protein  
18 BCG_2651c −1.69 −2.18 Rv2624c   hypothetical protein  
  BCG_2652c −2.00 −2.32 Rv2625c   transmembrane alanine and leucine rich protein  
  BCG_2653c −1.84   Rv2626c   hypothetical protein Up
  BCG_2654c −1.84 −1.03 Rv2627c   hypothetical protein  
  BCG_2655 −2.40 −1.36 Rv2628   hypothetical protein  
  BCG_2656 −1.29 −1.56 Rv2629   hypothetical protein  
  BCG_2657 −1.22 −1.74 Rv2630   hypothetical protein  
  BCG_2658 −1.15 −1.36 Rv2631   hypothetical protein  
19 BCG_3155c −1.69 −2.18 Rv3132c devS two component sensor histidine kinase devS Up
  BCG_3156c −1.56 −1.94 Rv3133c devR two component transcriptional regulatory protein DevR  
  BCG_3157c −1.84 −2.32 Rv3134c   hypothetical protein  
20 BCG_3520c 2.08 1.96 Rv3455c truA tRNA pseudouridine synthase A Up
  BCG_3521c 1.19   Rv3456c rplQ 50S ribosomal protein L17  
  BCG_3522c 1.44 1.53 Rv3457c rpoA DNA-directed RNA polymerase subunit alpha  

*log 2 transformed expression values in microarray analysis.

**ChIP-seq peaks identified in inbR overexpressed strain. Up, upstream of the operon or gene; Dn, downstream of the operon/gene; In, inside of a gene; NA, peak is not available. Peaks are visualized in Figure 5 and Figure S7.