Figure 3.

Sequence alignment of α7 nAChRs from 10 different species. Secondary structures are shown schematically above the sequences, based on the X-ray structure of the 5-HT_3A receptor (PDB CODE: 4PIR). Some of the residues important for construct optimization are highlighted by red arrows. NCBI Reference Sequence: H sapiens, NP_000737.1; G gallus, NP_989512.2; T guttata, XP_002196642.1; O cuniculus, XP_002718333.1; A melanoleuca, XP_002929231.1; C familiaris, XP_545813.2; B taurus, NP_776940.1; D rerio, NP_957513.1; T castaneum, ABS86911.1; A gambiae, XP_314691.2.