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. 2015 Jun 15;36(8):987–997. doi: 10.1038/aps.2015.37

Figure 2.

Figure 2

Wogonin inhibited OPN expression and secretion in 3T3-L1 adipocytes. (A and B) Dose-response (A) and time-response (B) of wogonin on OPN protein expression. 3T3-L1 adipocytes were incubated in complete medium containing 25 mmol/L glucose and received indicated concentrations of wogonin for 12 h (A) or 10 μmol/L wogonin for the indicated time (B). (C) Effect of wogonin on the expression of OPN mRNA. (D) Effect of wogonin on OPN concentration in cultured medium. For (C and D), 3T3-L1 adipocytes exposed to 25 mmol/L glucose were treated with or without 10 μmol/L wogonin for 12 h. bP<0.05, cP<0.01 vs DMSO control group. OPN, osteopontin; Wog, wogonin.