Figure 4.

Effective Size of the of UK Population

The threshold on IBD length is 2 cM for the UK10K sequence data and 4 cM for the WTCCC2 SNP array data. Estimated effective sizes are shown for 200 generations for the UK10K sequence data (upper left panel), whereas only 50 generations are shown for the WTCCC2 data (upper right panel) because they are derived from SNP array data. Bootstrap 95% confidence intervals are shown as shaded regions. The lower left panel overlays the results for the TWINSUK cohort with the results of the full WTCCC2 data. The lower right panel shows the ratio of estimated effective size to census size (open circle) and bootstrap 95% confidence intervals (vertical lines). The effective sizes are from the WTCCC2 analysis, and the census sizes are for Great Britain (England, Wales, and Scotland) for the years shown under the x axis.