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. 2015 Jun 30;39(10):1539–1547. doi: 10.1038/ijo.2015.102

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Copyright © 2015 Macmillan Publishers Limited

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Effect of obesogenic diet and estrogen treatment on adiposity and metabolism in male mice. Male mice were fed control (CON) or obesogenic (DIO) diet from 5 weeks of age and at 6 weeks underwent implantation of a continuous release 17β-estradiol pellet (estradiol) or sham surgery (sham). (a) Body weight over duration of study. (b) Adipose mass as percentage of body weight. SC, subcutaneous; Mes, mesenteric; RP, retroperitoneal; Epi, epididymal. Plasma glucose (c) and insulin (d) during a glucose tolerance test. AUC glucose: sham CON 859.2±123.7; sham DIO 1290.6±110.8; estrodiol CON 596.9±32.3; estrodiol DIO 759.3±46.3. AUC insulin: sham CON 41.0±5.8; sham DIO 185.8±9.9; estrodiol CON 44.8±10.7; estrodiol DIO 55.0±6.5. Data are mean±s.e.m., n=11 per sham group, 12 per estradiol group, analyzed by repeated measures analysis of variance (ANOVA) (a, c and d) or two-way ANOVA (b), repeated measures where necessary. Effect of diet ***P<0.001; effect of estradiol ^†††P<0.001; interaction between effects ^∫P<0.05, ^∫∫P<0.01, ^∫∫∫P<0.001.