Table 2. Concentrations of lipids and corticosterone in obese and control mice.
|
Males |
Females |
Effect of dietP-value | Effect of sexP-value | Interaction diet and sexP-value | |||
|---|---|---|---|---|---|---|---|
| CON | DIO | CON | DIO | ||||
| Fasting plasma triglyceride (mmol l−1) | 0.57±0.03 | 0.78±0.05 | 0.41±0.03 | 0.54±0.02 | 0.000027 | 0.000005 | 0.21 |
| Total plasma cholesterol (mmol l−1) | 1.71±0.13 | 2.67±0.23 | 1.53±0.17 | 2.86±0.16 | <0.000001 | 0.55 | 0.56 |
| Hepatic triglyceride (nmol mg−1) | 27.5±3.7 | 60.6±8.6 | 26.5±3.0 | 58.5±3.8 | 0.000001 | 0.77 | 0.93 |
| Nadir plasma corticosterone (nm) | 64.8±8.0 | 70.8±7.6 | 66.6±14.3 | 62.1±10.0 | 0.94 | 0.74 | 0.60 |
| Peak plasma corticosterone (nm) | 282.0±43.0 | 177.0±26.2 | 457.3±62.0 | 375.0±33.1 | 0.03 | 0.0001 | 0.79 |
Male and female mice were fed control (CON) or obesogenic (DIO) diets from 5 weeks of age. Plasma lipid and corticosterone levels were measured in samples taken during metabolic tests. Hepatic triglyceride was analyzed in post-mortem tissue. Data are mean±s.e.m., analyzed by two-way analysis of variance n=8 per group.