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. 2015 Sep 9;11:54. doi: 10.1186/s12990-015-0060-z

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© Saeed et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Behavioral characterization at several time points following IB4-saporin injection. a Assessment of mechanical allodynia using von Frey filaments in IB4-saporin-treated and sham animals; mechanical thresholds were not significantly different from the sham group. b Assessment of mechanical hyperalgesia using pin prick in IB4-saporin-injected and sham groups; there was no significant difference in mechanical nociceptive rating between IB4-saporin-injected and sham groups. c Assessment of thermal hyperalgesia using the Hargreaves test in IB4-saporin-injected and sham groups; IB4-saporin-injected animals did not display a significant difference in withdrawal latencies at any of the time points studied following IB4-saporin injection when compared with the sham group. N = 6, two-way ANOVA with Bonferroni post hoc