Table 2.
HRs and 95% CIs for patient survival (OS) in association with MUC4 expression in enrolled studies
| First author | Publication year | Detecting method | Cut-off value | Case Number | HR (95% CI) | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| High expression | Low expression | OS | DFS/RFS/PFS | ||||
| Higashi1 | 2015 | IHC-8G7 | 10% | 106 | 8 | 1.00 (0.31-4.12) M | NA |
| Majhi | 2013 | NA | Score >12 | 16 | 13 | 0.32 (0.05-1.92) U* | NA |
| Khanh | 2013 | IHC-1G8 | 5% | 68 | 138 | 1.51 (0.91-2.53)M | 2.30 (1.21-4.36) M |
| Lee | 2012 | IHC-1G8 | 5% | 35 | 28 | 2.89 (0.884-9.451) M | NA |
| Higashi2 | 2012 | IHC-8G7 | 5% | 19 | 44 | 1.73 (0.83-3.60) M | NA |
| Hamada | 2012 | IHC-8G7 | 5% | 61 | 89 | 1.619 (1.115-2.409) M | 1.00 (0.97-1.03) U* |
| Yi Zhu | 2011 | qRT-PCR | 50% | 29 | 28 | 2.571 (1.277-5.177) M | NA |
| Shanmugam | 2010 | IHC-8G7 | 75% | 33 | 99 | 2.07 (1.14-3.75) M | NA |
| Aloysius | 2010 | IHC-1G8 | 5% | 53 | 51 | 1.79 (0.88-3.7) M | NA |
| Yeh CN | 2009 | IHC-1G8 | 1% | 13 | 38 | 3.40 (1.56-7.41) M | NA |
| Westgaard | 2009 | IHC-1G8 | 10% | 44 | 21 | 2.02 (1.02-3.98) U* | NA |
| Tsutsumida | 2007 | IHC-8G7 | 25% | 25 | 160 | 3.21 (1.39-7.42) U* | 1.00 (0.96-1.04) U* |
| Morrison | 2007 | IHC-1G8 | 5% | 69 | 226 | 2.15 (0.85-5.48) M | 1.44 (0.51-4.04) M |
| Tamada | 2006 | IHC-8G7 | 5% | 19 | 51 | 2.655 (1.125-6.625) M | NA |
| Chauhan | 2006 | IHC-8G7 | 25% | 23 | 15 | 1.61 (0.5-5.23) U* | NA |
| Saitou | 2005 | IHC-8G7 | 5% | 21 | 114 | 1.956 (1.13-3.384) M | NA |
| Weed | 2004 | IHC-1G8 | 10% | 19 | 130 | 0.27 (0.08-0.88) M | 0.27 (0.10-0.77) M |
| Shibahara | 2004 | IHC-8G7 | 5% | 10 | 17 | 4.560 (1.190-17.478) M | NA |
The source of HR and 95% CI is described as derived from univariate analysis (U) or multivariateanalysis (M).
*
HR and 95% CI calculated from survival curves.
OS, overall survival; DFS, disease-free survival; RFS, recurrence-free survival; PFS, progression-free survival; HR, HR (high vslow); qRT-PCR, quantitative real-time PCR; NA, not available; IHC-1G8: Immunohistochemistryusing 1G8 antibody; IHC-8G7: Immunohistochemistry using 8G7 antibody.