Table 1.
Characteristics of the selected 32 clinical trials
| References/Year/country | Type of gastrectomy | LG/No. patients | OG/No. patients | Main conclusions |
|---|---|---|---|---|
| [3]/2013/Japan | EGC | 3937 | 5451 | No differences in early mortality or morbidity, LG has slight reduction in postoperative length of stay. |
| [4]/3013/China | Distal | 54 | 54 | LG and OG achieve similar short- and long-term results. |
| [5]/2013/Japan | D2 for AGC | 186 | 150 | LG may offer a favorable alternative to OG. |
| [6]/2013/Korea | total gastrectomy | 35 | 35 | Postoperative complications were observed more frequently in LG. |
| [7]/2013/Japan | Distal | 31 | 32 | LG results in less postoperative pain, decreased surgical invasiveness and fewer postoperative inconveniences. |
| [8]/2013/Korea | EGC | 1,013 | 1,112 | LG showed a shorter operation time, a shorter postoperative hospital stay, a lower overall complication rate, and a comparable survival rate. In total gastrectomy, LG was associated with a higher complication rate. |
| [9]/2013/China | AGC | 83 | 83 | LG with D2 lymphadenectomy is a safe and feasible for AGC without serosal invasion. |
| [10]/2013/Korea | Total | 120 | 228 | LG has better short-term outcomes and similar long-term outcome. |
| [11]/2013/Korea | Distal or total, D2 | 1,058 | 816 | LG is an oncologically safe, with comparable long-term outcomes with OG. |
| [12]/2013/Korea | Total or distal subtotal | 74 | 36 | LG showed comparable oncologic outcomes to OG. |
| [13]/2013/Japan | Proximal | 22 | 68 | LG may lead to faster recovery, better cosmesis, and improved quality of life in the short-term. |
| [14]/2013/Korea | T3N2M0 | 139 | 207 | LG is a safe, less invasive and results in faster recovery than OG. |
| [15]/2013/Japan | AGC, T4 | 66 | 135 | LG should be considered as a feasible alternative to OG for the treatment of AGC. |
| [16]/2013/Italy | Subtotal or total | 41 | 41 | LG is a safe with favorable short-term outcomes, comparing to OG. |
| [17]/2013/China | Total | 117 | 117 | LG is feasible for AGC short- and long-term oncologic outcomes are comparable with OG. |
| [18]/2012/China | Wedge resection | 68 | 88 | LG could get preferable short-term outcomes and similar long-term relapse-free survival compared with OG. |
| [19]/2012/Japan | Distal or pylorus-preserving | 129 | 136 | LG for EGC is feasible in terms of the incidence and severity of intra-abdominal complications. |
| [20]/2012/Japan | EGC, AGC | 158 | 174 | LG with D1, D1+ for EGC is equivalent to OG in curability. LG with D2 for AGC is comparable to OG with regard to short-and long-term results. |
| [21]/2012/Chile | EGC, AGC | 31 | 31 | The 3-year overall and stage-by-stage survival was comparable for LG and OG. |
| [22]/2012/Canada | AGC, proximal, total, subtotal, or distal | 21 | 182 | LG is safe for AGC with outcomes similar to OG. |
| [23]/2012/Korea | Distal | 1002 | 629 | LG is less invasive than the OG in terms of morbidity, and fewer complications. |
| [24]/2012/Korea | AGC | 89 | 345 | LG for AGC might be considered to be a minimally invasive surgery in selected cases. |
| [25]/2012/China | PG,DG or TG +D2 | 131 | 78 | LG D2 is equivalent to OG in the number of HLNs, regardless of tumor location. |
| [26]/2012/Korea | Distal, pT2 cancer | 52 | 67 | LG might be considered as an alternative treatment for some pT2 gastric cancer. |
| [27]/2011/China | AGC | 346 | 313 | LG for AGC is safe and effective. it did not differ significantly from OG in terms of survival rate or recurrence, and has the advantages less bleeding, rapid postoperative recovery, and fewer complications. |
| [28]/2011/Italy | AGC | 22 | 25 | LG is as effective as OG in AGC. |
| [29]/2011/Italy | Locally AGC | 30 | 30 | LG is for AGC and associated with additional benefits as a decreased length of hospital stay, a decreased narcotic use and fewer complications. |
| [30]/2011/Italy | Distal, total | 109 | 269 | LAG is a feasible and safe procedure and has several advantages despite a higher rate of morbidity. |
| [31]/2010/China | Distal | 50 | 50 | LG seems to be a safe and feasible for EGC, with potential disadvantages. |
| [32]/2010/Korea | Distal | 179 | 161 | There was no significance difference in the morbidity and mortality between the 2 groups. |
| [33]/2010/Korea | EGC | 42 | 162 | There was no significance difference in the morbidity and mortality between the 2 groups. |
| [34]/2009/Korea | Distal | 45 | 83 | LG with extended lymphadenectomy for AGC is a feasible and safe and has several advantages. |